Thermoplastic PCL-b-PEG-b-PCL and HDI Polyurethanes for Extrusion-Based 3D-Printing of Tough Hydrogels

Alternating block polyurethanes based on PCL and PEG as potential nerve regeneration materials.

Polyurethanes with regular and controlled block arrangement, i.e., alternating block polyurethanes (abbreviated as PUCL-alt-PEG) based on poly(ε-caprolactone) (PCL-diol) and poly(ethylene glycol) (PEG) was prepared via selectively coupling reaction between PCL-diol and diisocyanate end-capped PEG. Chemical structure, molecular weight, distribution, and thermal properties were systematically cha...

Preparation and evaluation of PCL-PEG-PCL micelles as potential nanocarriers for ocular delivery of dexamethasone

Objective(s): Micelles have been studied as nanoparticulate drug delivery systems for improving the topical ocular delivery of hydrophobic drugs. The objective of this study was to develop and characterize dexamethasone-loaded polycaprolactone-polyethylene glycol-polycaprolactone (PCL-PEG-PCL) micelles to improve patient compliance and enhance the ocular bioavailability of poorly water-soluble ...

Preparation and Characterization of PCL-PEG-PCL Copolymeric Nanoparticles as Polymersomes for Delivery Hydrophilic Drugs

Background: A novel drug delivery system using poly (ε-caprolactone) - poly (ethylene glycol) -poly (ε-caprolactone) (PCL-PEG-PCL) was established in this study. Methods: Ceftriaxone (CTX) was encapsulated within PCL-PEG-PCL nanoparticles by a double emulsion technique (w/o/w), leading to creation of ceftriaxone-loaded PCL-PEG-PCL (CTX/PCL-PEG-PCL) polymersomes. The resulting polymersomes...

Preparation and evaluation of PCL-PEG-PCL micelles as potential nanocarriers for ocular delivery of dexamethasone

Objectives Micelles have been studied as nanoparticulate drug delivery systems for improving the topical ocular delivery of hydrophobic drugs. The objective of this study was to develop and characterize dexamethasone-loaded polycaprolactone-polyethylene glycol-polycaprolactone (PCL-PEG-PCL) micelles to improve patient compliance and enhance the ocular bioavailability of poorly water-soluble dru...

preparation of hydrogels based on inclusion complexes of the triblock copolymer pcl-peg-pcl with α-cyclodextrin (α-cd)